Short answer
Buenos Aires is usually best for liquidity and rental depth. Mendoza is best for wine-country lifestyle and hospitality. Patagonia is best for scarcity, nature, and high-emotion ownership with more legal and operational screening.
Investment lens
Buenos Aires has the clearest comparables. Mendoza can blend lifestyle with hospitality. Patagonia often depends on scarce inventory, project viability, and buyer patience.
Lifestyle lens
City buyers should start in Buenos Aires. Wine and food buyers should compare Mendoza submarkets. Mountain and lake buyers should look at Bariloche, Villa La Angostura, and San Martin de los Andes with border-zone review.